Comparison of the activities of prostamide F2α with standard receptor selective prostanoids in human platelet, human dermal fibroblast (CRL 1497), and isolated tissue preparations
n = 4 for all preparations; n = 6 for the rabbit isolated jugular vein.
Receptor Subtype | Preparation | Prostamide F2α EC50 | Receptor Selective Prostanoid EC50 (nM) |
|---|---|---|---|
| DP | Inhibition of ADP-induced human platelet aggregation | NA | PGD2 = 79 |
| EP1 | Guinea pig ileum | >10,000 | PGE2 = 6 |
| EP3 | Inhibition of field stimulated guinea pig vas deferens | 1585 | Sulprostone = 0.2 |
| FP | Relaxation of rabbit jugular vein | 2000 | PGF2α = 2.8 |
| CRL 1497 fibroblasts | 1586 | PGF2α = 25 | |
| IP | Inhibition of ADP-induced human platelet aggregation | NA | Carbaprostacyclin = 708 |
| TP | Rat aorta contraction | >10,000 | U-46619 = 10 |
NA, not active.