Effect of SSR240612 on splanchnic artery occlusion/reperfusion-induced intestinal tissue injury and neutrophil accumulation in rats The degree of tissue damage was estimated by the reduction of the intestine weight. Neutrophil accumulation in intestinal tissue was investigated through MPO activity. Values are means ± S.E.M. obtained from 12 to 16 independent experiments.
Group | Weight of Intestine (Mean ± S.E.M.) | MPO (Mean ± S.E.M.) |
|---|---|---|
| g (n) | δAU / min / mg protein (n) | |
| Sham | 7.450 ± 0.197 (16) | 401 ± 34 (16) |
| Control | 5.454 ± 0.210 (16)* | 1030 ± 144 (16)* |
| SSR240612 | ||
| 0.03 mg/kg (i.v.) | 5.630 ± 0.206 (12) | 1147 ± 172 (12) |
| 0.3 mg/kg (i.v.) | 6.594 ± 0.213 (16)** | 530 ± 50 (16)** |