Ki of SSR240612 on B2 kinin receptors of guinea pig ileum membranes and CHO cells expressing human B2 receptor, using [3H]bradykinin as ligand and B1 receptors of human fibroblast MRC5, and HEK cells expressing human B1 receptors, using [3H]Lys-des-Arg9-BK as ligand Values are means ± S.E.M. of data obtained from at least three independent experiments performed in triplicate.
B1 Human MRC5 | B1 Human HEK-B1 | B2 Guinea Pig Ileum Membranes | B2 Human CHO-B2 | ||
|---|---|---|---|---|---|
| nM | |||||
|
K
i
| 0.48 ± 0.04 | 0.73 ± 0.06 | 481 ± 107 | 358 ± 92 | |