Alterations in the discriminative-stimulus potency of cocaine produced by treatment with N-substituted BZT analogs ED50 values and potencies relative to cocaine alone (with 95% CL) are shown.
Drug | ED50 (μmol/kg) | Relative Potencya |
|---|---|---|
| Cocaine | 9.68 (6.62-13.9) | 1.0 |
| 0.18 WIN 35,428 + cocaine | 5.83b (3.30-22.9) | 1.24 (0.643-2.09) |
| 1.77 WIN 35,428 + cocaine | Nonsignificant linear regression | 574 c (260-1810) |
| 0.76 AHN 1-055 and cocaine | 14.1 (8.15-37.6) | 0.657 (0.353-1.14) |
| 2.54 AHN 1-055 and cocaine | 9.85 (4.85-22.0) | 0.903 (0.491-1.63) |
| 3.6 AHN 1-055 and cocaine | 9.65 (6.39-13.7) | 1.13 (0.750-1.75) |
| 14.2 AHN 1-055 and cocaine | Nonsignificant linear regression | 1.94 (1.03-4.30) |
| 2.73 AHN 2-003 + cocaine | 8.32 (4.88-14.2) | 1.06 (0.601-1.87) |
| 8.20 AHN 2-003 + cocaine | 6.97 (4.21-10.5) | 1.26 (0.776-2.10) |
| 15.3 AHN 2-003 + cocaine | Nonsignificant linear regression | 0.919 (0.508-1.68) |
| 2.37 JHW 007 + cocaine | 13.4 (9.32-21.7) | 0.682 (0.382-1.15) |
| 7.11 JHW 007 + cocaine | 10.1 (6.62-15.7) | 0.880 (0.518-1.48) |
| 23.7 JHW 007 + cocaine | Nonsignificant linear regression | 1.66c (0.766-4.20) |
| 13.8 AHN 2-005 + cocaine | 6.94b (5.35-8.68) | 1.29 (0.849-2.00) |
| 24.6 AHN 2-005 + cocaine | Nonsignificant linear regression | 1.12c (0.490-2.69) |
| 5.60 JHW 005 + cocaine | 6.53 (3.38-10.3) | 1.33 (0.800-2.31) |
| 10.5 JHW 005 + cocaine | 7.00 (3.00-12.5) | 1.21 (0.696-2.19) |
| 18.7 JHW 005 + cocaine | Nonsignificant linear regression |
2.15
c
,
d
(1.04-5.77)
|