Effect of U73122 on binding of steroid receptors
The data represent the percentage of inhibition of GR, ERα, ERβ, and AR binding by U73122 at 10 μ M. Duplicate runs were performed against each receptor. The IC50 values of control compounds are as indicated.
Receptor | U73122 | Inhibition | Control Compound | Control IC50 |
|---|---|---|---|---|
| μM | % | nM | ||
| GR | 10 | Dexamethasene | 26 | |
| ERα | 10 | 17 β-Estradiol | 3.9 | |
| ERβ | 10 | Ethinylestradiol | 4.6 | |
| AR | 10 |
| DHT | 9 |
DHT, dihydrotestosterone; GR, glucocorticoid receptor.