Agonist | CPPHA EC50 for Potentiation | Maximum Potentiation, CPPHAa | DFB EC50 for Potentiation | Maximum Potentiation, DFBa |
---|---|---|---|---|
μM | μM | |||
Human mGluR5a CHO Cells | ||||
300 nM Glutamate | 0.393 ± 0.037 (11) | 6.8-fold | 2.3 ± 0.6 (7) | 4.2-fold |
1 μM 3,5-DHPG | 0.316 ± 0.045 (4) | 3.2-fold | 2.5 ± 0.6 (11) | 3.4-fold |
8 nM Quisqualate | 0.500 ± 0.145 (4) | 4.0-fold | 2.4 ± 0.5 (8) | 3.5-fold |
Rat mGluR5 CHO Cells | ||||
300 nM Glutamate | 0.81 ± 0.19 (4) | 7.9-fold | 7.2 ± 1.9 (6) | 6.1-fold |
1 μM 3,5-DHPG | 0.634 ± 0.071 (4) | 5.4-fold | 4.2 ± 1.1 (6) | 4.9-fold |
8 nM Quisqualate | 1.16 ± 0.38 (4) | 7.6-fold | 4.4 ± 1.2 (5) | 6.7-fold |