Hemodynamic parameters and coronary flow in I/R, IL-2, and U50,488H groups Values are expressed as mean ± S.E.M. (n = 8 in each group).
Variable | Baseline | Ischemia | Reperfusion | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 min | 30 min | 10 min | 60 min | 120 min | ||||||
| LVDP | I/R | 112.4 ± 3.4 | 54.4 ± 3.7 | 60.4 ± 3.11 | 78.8 ± 2.9 | 62.5 ± 3.3 | 49.0 ± 2.0 | |||
| (mm Hg) | IL-2 | 113.1 ± 2.2 | 68.9 ± 5.1* | 72.4 ± 4.1* | 75.1 ± 3.7 | 74.1 ± 2.5* | 61.7 ± 2.2** | |||
| U50 | 107.7 ± 1.9 | 62.1 ± 3.5 | 68.9 ± 4.9 | 85.2 ± 4.1 | 75.29 ± 3.6* | 67.0 ± 3.5** | ||||
| LVEDP | I/R | 4.5 ± 0.3 | 8.5 ± 0.9 | 10.5 ± 1.4 | 21.3 ± 2.87 | 21.0 ± 2.6 | 24.7 ± 2.2 | |||
| (mm Hg) | IL-2 | 4.2 ± 0.3 | 8.5 ± 1.1 | 14.9 ± 2.0 | 20.5 ± 3.0 | 26.3 ± 3.5 | 22.8 ± 2.8 | |||
| U50,488H | 6.7 ± 0.6 | 7.4 ± 0.6 | 11.4 ± 1.1 | 24.6 ± 3.7 | 26.7 ± 2.2 | 29.2 ± 2.2 | ||||
| +dP/dtmax | I/R | 2127 ± 72 | 1295 ± 46 | 1400 ± 46 | 1678 ± 76 | 1552 ± 45 | 1168 ± 42 | |||
| (mm Hg/s) | IL-2 | 2116 ± 54 | 1534 ± 69* | 1599 ± 29** | 1611 ± 60 | 1536 ± 65 | 1402 ± 64* | |||
| U50,488H | 2109 ± 47 | 1205 ± 92 | 1,335 ± 130 | 1,575 ± 98 | 1424 ± 66 | 1355 ± 70* | ||||
| -dP/dtmax | I/R | 1879 ± 56 | 1114 ± 51 | 1170 ± 47 | 1421 ± 50 | 1274 ± 68 | 1039 ± 41 | |||
| (mm Hg/s) | IL-2 | 1905 ± 32 | 1308 ± 60* | 1342 ± 42* | 1397 ± 53 | 1286 ± 34 | 1220 ± 55* | |||
| U50,488H | 1946 ± 29 | 1028 ± 105 | 1196 ± 99 | 1292 ± 74 | 1176 ± 26 | 1164 ± 24 | ||||
| LVDP × HR | I/R | 33,607 ± 949 | 15,828 ± 1226 | 17,615 ± 1191 | 17,137 ± 4085 | 12,837 ± 3180 | 10,243 ± 978 | |||
| IL-2 | 33,358 ± 693 | 18,412 ± 1575 | 17,339 ± 1492 | 18,356 ± 1940 | 17,423 ± 943 | 14,447 ± 553* | ||||
| U50,488H | 31,267 ± 919 | 16,757 ± 966 | 17,338 ± 1047 | 20,833 ± 1107 | 17,680 ± 1102 | 15,064 ± 895* | ||||
| HR | I/R | 299.1 ± 4.8 | 290.3 ± 8.1 | 290.5 ± 7.9 | 280.3 ± 14.5 | 267.4 ± 12.1 | 234.9 ± 10.9 | |||
| (beats/min) | IL-2 | 295.0 ± 4.3 | 268.2 ± 14.9 | 238.7 ± 12.4 | 241.0 ± 16.2 | 234.3 ± 6.2 | 233.8 ± 2.9 | |||
| U50,488H | 289.4 ± 7.3 | 270.2 ± 7.5 | 252.8 ± 5.4* | 242.2 ± 5.1 | 234.4 ± 8.1 | 224.6 ± 5.6 | ||||
| CF | I/R | 9.6 ± 0.5 | 6.1 ± 0.2 | 5.3 ± 0.2 | 7.2 ± 0.3 | 5.1 ± 0.4 | 3.8 ± 0.1 | |||
| (ml/min) | IL-2 | 11.8 ± 0.50 | 6.7 ± 0.5 | 5.8 ± 0.4 | 7.0 ± 0.4 | 5.5 ± 0.6 | 4.7 ± 0.4 | |||
|
| U50,488H | 9.0 ± 0.3 | 5.2 ± 0.2 | 4.9 ± 0.1 | 7.0 ± 0.4 | 6.2 ± 0.5 | 4.6 ± 0.2 | |||