Dose-response parameters for P2 agonist-induced mobilization of intracellular Ca2+ in trabecular meshwork cells
Agonist | Bovine Trabecular Cells | HTM-3 Cell Line | ||||
|---|---|---|---|---|---|---|
| EC50 | Response Maximum | EC50 | Response Maximum | |||
| μmol/l | % increase | μmol/l | % increase | |||
| ATP | 0.58 | 428 | 0.27 | 287 | ||
| UTP | 0.37 | 419 | 0.20 | 267 | ||
| ADP | 0.35 | 269 | 0.053 | 177 | ||
| 2-MeS-ATP | 0.070 | 225 | 0.048 | 172 | ||
| UDP | ND | ND | ND | ND | ||
Parameters for UDP were not determined (ND) because this agonist did not produce any significant elevation in intracellular Ca2+ at the concentrations tested.