Inhibition of Ang II-Induced HT | Inhibition of bigET-1-Induced HT | ||
---|---|---|---|
ED50 μmol / kg | |||
Compound A, i.v., p.o. | Inactive | 0.9, 8.1 | |
Irbesartan, i.v., p.o. | 0.3, 10.3 | Inactive | |
Compound C, i.v., p.o. | 1.4, 39.0 | 2.1, 26.0 | |
Compound D, i.v., p.o. | 0.8, 3.6 | 7.6, 10.9 | |
Compound E, p.o. | n.d. | 1.0 |
HT, hypertension; n.d., not determined.