TABLE 2

Functional potencies (Kb apparent) of irbesartan, compound A, and DARA compound C

Irbesartan
Compound A
Compound C
Rat AT1 Kb apparent (nM) 0.29 ± 0.08 N.D. 9.6 ± 3.4
Human ETA Kb apparent (nM)
N.D.
0.41 ± 0.06
3.8 ± 1.6

  • N.D., not determined.