TABLE 2

Dynamic parameters for effects of methylprednisolone on PEPCK regulation

Parameter	Estimate	CV%
cAMP Dynamics
(h⁻¹)	0.27	17
(fmol/mg protein)	433^a,b,d/17.81^c,e	20^a,b/9^c
cAMP⁰ (pmol/g liver)	654.4^a/656.1^b/806.1^c/562.7^d/740.5^e	Fixed
(pmol/g liver/h)	176.7^a/177.1^b/217.6^c	17
PEPCK mRNA Dynamics
k₁ (h⁻¹)	0.75	13
(h⁻¹)	0.017	38
(fmol/mg protein)⁻¹	2.11	52
(fmol/mg protein)⁻¹	2.90	51
PEPCK mRNA⁰ (fmol/g liver)	383.4^a/209.0^b/429.8^c	Fixed
(fmol/g liver/h)	6.46^a/3.52^b/7.24^c	38
PEPCK Dynamics
(h⁻¹)	0.22	12
γ	0.004	—^g
	1.17	10
(fmol/g liver)	0.0055	—^g
PEPCK⁰ (μmol ATP/min/g liver)	1.40^a,b/1.83^c/1.98^d/2.07^e	Fixed
(μmol ATP/min/g liver/h)/(fmol/g liver)^γ	0.30^a,b/0.39^c	12

^a 10 mg/kg i.v. injection; ^b 50 mg/kg i.v. injection; ^c infusion; ^d validation study (injection); ^e validation study (infusion); ^f secondary parameter; ^g not available.