Binding selectivity profile of TC-1698 Data are mean percent inhibition of control binding (or activity) for duplicate determinations. No data denotes less than 25% change in binding at 10 μM TC-1698. For all non-nicotinic receptors tested, TC-1698 had an IC50 > 1 μM.
Binding Site | Radioligand | Inhibition (Percentage at 10 μM) |
|---|---|---|
| Acetylcholinesterase | Acetylthiocholine | |
| Adenosine, nonselective | [3H]NECA | |
| Adrenergic α1 (rat cortex) | [3H]MeOxy-prazocin | |
| Adrenergic α2 (rat cortex) | [3H]RX-821002 | |
| Adrenergic β nonselective | [3H]DHA | |
| Angiotensin AT1 (human) | [125I]-(Sar1-Ile8) angiotensin | |
| Angiotensin AT2 | [125I]Tyr4-angiotensin II | |
| Calcium channel, type L | [3H]Nitrendipine | |
| Bradykinin, BK2 | [3H]Bradykinin | |
| Calcium channel, type N | [3H]contoxin GVIA | |
| Cholecystokinin, CCK1 (CCKA) | [125I]CCK-8 | |
| Cholecystokinin, CCK2 (CCKB) | [125I]CCK-8 | |
| Choline acetyltransferase | [14C]-Acetyl Coenzyme | |
| Glutamic acid decarboxylase | [14C]-Glutamic Acid | |
| Corticotropin-releasing factor | [3H]-Tyr0-oCRF | |
| Dopamine D3 (rat recombinant) | [3H]Spiperone | |
| Dopamine transporter | [3H]-WIN 35,428 | |
| Endothelin ET-A (Human) | [125I]-Endothelin1 | |
| Endothelin ET-B (Human) | [125I]-Endothelin1 | |
| GABA (rat cortex) | [3H]-GABA | |
| Estrogen | [125I] 3,17B-Estradiol, 16a | |
| GABA-A, BDZ, α1, central | [3H]-Flunitrazepam | |
| GABA-B transporter (rat cortex) | [3H]-CGP 5462A | |
| Galanin, nonselective | [125I] Galanin | |
| Glycine (rat spinal cord) | [3H]-Strychnine | |
| Histamine H1 periph. (guinea pig lung) | [3H]-Pyrilamine | |
| Histamine H1 | [3H]-Pyrilamine | |
| Histamine H2 | [3H]-Pyrilamine | 39 |
| Histamine H3 | [3H]-Pyrilamine | 60 |
| Leukotriene B4, LTB4 | [3H]-LTB4 | |
| Leukotriene D4, LTD4 | [3H]-LTD4 | |
| Melatonin ML1 (chicken brain) | [125I]-Iodomelatonin | |
| Monoamine oxidase A, peripheral | [14C]-5HT | |
| Monoamine oxidase B, peripheral | [14C]phenylethylamine | |
| Muscarinic, M1 (human recombinant) | [3H]-QNB | |
| Muscarinic, M2 (human recombinant) | [3H]-QNB | 46 |
| Muscarinic, nonselective central | [3H]-QNB | |
| Muscarinic, nonselective, peripheral | [3H]-QNB | |
| Neurokinin, NK1 | [3H]-SP | |
| Neurokinin, NK2 (human recombinant) | [3H]-NKA | |
| Neurokinin, NK3 (NKB) | [3H]-Eledoisin | |
| Nicotinic (rat cortex) | [3H]-Cytisine | 104 |
| Norepinephrine transporter (rat cortex) | [3H]-Nisoxetine | |
| NOS (neuronal-binding) | [3H]-NOARG | |
| Opioids (rat cortex) | [3H]-Naloxone | |
| Oxytocin (rat uterus) | [3H]-oxytocin | |
| Platelet-activating factor, PAF | Hexadecyl-[3H]-acetyl-PAF | |
| Potassium KATP channels (rat cortex) | [3H]-Glibenclamide | |
| Potassium KVI channels (rat cortex) | [125I]-Apamin | |
| Potassium KVS channels (rat cortex) | [125I]-Charybdotoxin | |
| Serotonin transporter | [3H]-Citalopram, N-methyl | |
| Serotonin, nonselective | [125I]-LSD | |
| Sigma (rat cortex) | [3H]-DTG | 35 |
| Sodium channels site 2 (rat cortex) | [3H]-Batrachotoxin | |
| Testosterone (cytosolic) | [3H]-Methyltrienolone | |
| Thromboxane A2 (Human) | [3H]-SQ 29,548 | |
| Thyrotropin-releasing hormone, TRH | [3H]-(3MeHis2)TRH | |
| Vasoactive intestinal peptide | [125I]-VIP | |
| Vasopressin V1 (rat aortic A7r5 cells) | [3H]-AVP |
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