TABLE 3

Comparison of AD50, potency ratio and half-maximal response decays of HN and related nonpeptides in the mouse tail-flick pain assay

Compound
AD50 (nmol/mouse) (95% CL)a
Potency Ratiob (95% CL)
Time of Half-Maximal Response Decayc (min)
HN 114 (92-141) 1.0 45
1 9.6 (2.1-50) 11.8 (1.8-67.1)* 28.5
2 14.2 (11.5-17.4) 8.0 (5.3-12.3)* 21.3
4 98.6 (70-139) 1.1 (0.7-2.0) 18.5
6 31.7 (22.9-43.8) 3.6 (2.1-6.1)* 16.7
7
13.1 (10.6-16.1)
8.7 (8.6-13.3)*
28.9

  • ↵* P ≤ 0.05 compared with HN

  • ↵ a 95% confidence limit (CL)

  • ↵ b Relative to HN

  • ↵ c Tested at 50 nmol i.c.v. for HN and 10 nmol i.c.v. for the nonpeptides