Comparison of AD50, potency ratio and half-maximal response decays of HN and related nonpeptides in the mouse writhing pain assay
Compound | AD50 (nmol/mouse)a (95% CL) | Potency Ratiob (95% CL) | Time of Half-Maximal Response Decayc |
|---|---|---|---|
| min | |||
| HN | 23.0 (12.5-47.0) | 1.0 | 22 |
| H4-(86-100) | 23.5 (14.0-39.4) | 0.98 | 22.5 |
| HN-(7-15) | 8.5 (1.9-15.4) | 2.7 (0.81-24.7)* | <10 |
| 1 | 4.1 (3.2-7.4) | 5.5 (1.7-14.7)* | 36 |
| 2 | 6.5 (4.5-9.3) | 3.5 (1.3-10.4)* | 15 |
| 3 | 5.6 (3.5-8.8) | 4.1 (1.4-13.4)* | |
| 4 | 16.1 (9.9-26.3) | 1.4 (0.5-4.7) | 19 |
| 5 | 12.8 (10.0-16.3) | 1.8 (0.8-4.7) | 35 |
| 6 | 3.2 (1.8-5.6) | 7.3 (2.2-26.1)* | 58 |
| 7 | 2.6 (1.5-4.5) | 8.8 (2.8-31.3)* | 36 |