Comparisons of CYP2C19 (S)-mephenytoin 4-hydroxylase metabolic activity
Data Source | Sample Size | Median Age | Median-Specific Activitya | Specific Activity Rangea |
|---|---|---|---|---|
| yr | pmol / min / mg | pmol / min / mg | ||
| Current study >10 to 18 yr | 19 | 15.2 | 18.5 | 0.4-101.7 |
| Chiba et al. (1993) | 14 | NA | 55.5 | 15.0-173.0 |
| Goldstein et al. (1994)b | 15 | NA | 145.0 | 12.0-388.0 |
| Pearce et al. (1996) | 9 | 51 | 38.4 | 6.9-86.5 |
| Wrighton et al. (1993) | 13 | 29.5 | 66.0 | 2.0-310.0 |
| Heyn et al. (1996) | 14 | NA | 39.5 | 9.0-319.0 |
| BD Gentestb,c | 10 | 46.0 | 26.5 | 4.0-320.0 |
↵ a Values for those samples that exhibited detectable activity.
↵ b Excluded single outlier values with specific activity > 600 pmol/min/mg.
↵ c http://www.bdbiosciences.com.
Current study vs. Goldstein et al. (1994), p < 0.001 (Kruskal-Wallis); differences among all other groups were not significant.