TABLE 1

Ontogeny of CYP2C9 diclofenac 4-hydroxylase metabolic activity


Age Bracket

Sample Size

%ND

Median-Specific Activitya

Specific Activity Rangea
pmol/min/mg pmol/min/mg
Fetal
    8-40 wks 48 60 143 19-254
    25-40 wks 16 38 195 37-735
Postnatal
    0 to 5 mo 88 16 899 53-4600
    >5 mo to 18 yr
71
14
628
60-1996
  • a Values for those samples that exhibited detectable activity.