Effects of (+)-PD 128,907 on the toxicity induced by other agents
Different convulsants produced distinct seizure types (clonic, tonic, limbic). (+)-PD 128,907 s.c. was administered 30 min before application of the convulsant stimulus.
Convulsant | Effect | + Vehicle | + 3 mg/kg PD 128,907 | + 10 mg/kg PD 128,907 |
|---|---|---|---|---|
| GBR 12909 (170 mg/kg i.p.) | Clonus | 9/16 | 1/8* | 3/8 |
| Tonus | 0/16 | 0/8 | 0/8 | |
| Death | 0/16 | 0/8 | 0/8 | |
| GBR 12909 (300 mg/kg i.p.) | Clonus | 12/16 | 6/16* | 2/8* |
| Tonus | 0/16 | 0/16 | 0/8 | |
| Death | 0/16 | 0/16 | 0/8 | |
| Pentylenetetrazol (70 mg/kg i.p.) | Clonus | 10/12 | 5/8 | 7/8 |
| Tonus | 0/12 | 0/8 | 5/8* | |
| Death | 0/12 | 0/8 | 1/8 | |
| Bicuculline (6 mg/kg i.p.) | Clonus | 7/8 | 5/8 | 6/8 |
| Tonus | 6/8 | 4/8 | 1/8* | |
| Death | 6/8 | 4/8 | 1/8* | |
| Pictrotoxin (6 mg/kg i.p.) | Clonus | 11/12 | 6/8 | 7/8 |
| Tonus | 5/12 | 1/8 | 2/8 | |
| Death | 6/12 | 1/8 | 3/8 | |
| tert-Butyl | Clonus | 7/8 | 5/8 | 6/8 |
| biclyclophosphoorothionate (0.6 mg/kg i.p.) | Tonus | 7/8 | 4/8 | 4/8 |
| Death | 6/8 | 4/8 | 5/8 | |
| 4-Aminopyridine (14 mg/kg i.p.) | Clonus | 7/8 | 6/8 | 7/8 |
| Tonus | 7/8 | 6/8 | 7/8 | |
| Death | 7/8 | 6/8 | 7/8 | |
| Kainic acid (64 mg/kg i.p.) | Clonus | 8/8 | 7/8 | 7/8 |
| Tonus | 0/8 | 0/8 | 0/8 | |
| Death | 0/8 | 0/8 | 1/8 | |
| N-Methyl-d-aspartate (200 mg/kg i.p.) | Clonus | 10/12 | 7/8 | 5/8 |
| Tonus | 0/12 | 0/8 | 1/8 | |
| Death | 10/12 | 6/8 | 5/8 | |
| Pilocarpine (300 mg/kg i.p.) | Clonus | 11/11 | 7/8 | 6/8 |
| Tonus | 2/11 | 2/8 | 0/8 | |
| Death | 9/11 | 4/8 | 2/8* | |
| Nicotine (20 mg/kg i.p.) | Clonus | 7/8 | 6/8 | 5/6 |
| Tonus | 0/8 | 0/8 | 0/6 | |
| Death | 3/8 | 2/8 | 3/6 | |
| Nicotine (30 mg/kg i.p.) | Clonus | 16/16 | Nt | 8/8 |
| Tonus | 0/16 | Nt | 0/8 | |
| Death | 16/16 | Nt | 8/8 | |
| Strychnine (2 mg/kg i.p.) | Clonus | 15/16 | 8/8 | 8/8 |
| Tonus | 15/16 | 8/8 | 8/8 | |
| Death | 15/16 | 5/8 | 5/8 | |
| Aminophylline (300 mg/kg i.p.) | Clonus | 7/8 | 7/8 | 6/8 |
| Tonus | 7/8 | 7/8 | 6/8 | |
| Death | 7/8 | 6/8 | 6/8 | |
| Threshold electric shock | Tonus | 5/5 | 5/5 | Nt |
| 6 Hz | Clonusa | 5/5 | 5/5 | Nt |
| Sound | Tonus | 7/8 | 1/8* | Nt |