TABLE 1

Cumulative biliary excretion of GSCY, CY, and CEPM in Wistar and TR - rats over 3 h after intravenous administration of CY at 100 and 200 mg/kg

CY Dose
Bile Flow
GSCYa
CYa
CEPMa
μl/min/kg
100 mg/kg TR- 32 ± 4 ND 153.2 ± 61.7 26.2 ± 5.5
Wistar 99 ± 12 44.5 ± 8.6 415.6 ± 57.6 94.2 ± 5.9
Ratio (Wistar/TR-) 3.1 ND 2.7 3.6
p Valueb <0.001 <0.001 <0.001 <0.001
200 mg/kg TR- 36 ± 4 ND 392.4 ± 43.3 59.0 ± 17.8
Wistar 96 ± 12 128.8 ± 35.5 1223.2 ± 118.3 268.5 ± 111.0
Ratio (Wistar/TR-) 2.7 ND 3.1 4.6
p Valueb
<0.001
<0.001
<0.001
<0.001

  • ND, not detectable.

  • ↵ a Cumulative amount excreted in bile was calculated by multiplying peak area under LC-MS in 1 μl of bile by volume of bile (microliters) with normalization by rat body weight (grams). The unit is × 103 peak area per gram of body weight.

  • ↵ b p Value was determined by Student's t test between TR- and Wistar rats.