TABLE 3

Salvinorin A and salvinorinyl-2-propionate are agonist at hKOR-stimulated intracellular Ca2 mobilization: comparison with reference compounds

Data represent mean ±S.D. of quadruplicate determinations for EC50 and Emax for mobilization of intracellular calcium.


Drug

EC50 in nM (pEC50 ± SD)

Emax (Relative to U69593)
U69593 13 (1.14 ± 0.2) 100
U50488 24 (1.39 ± 0.14) 102 ± 4
Salvinorin A 7 (0.84 ± 0.07) 104 ± 7
Dynorphin A 83 (1.92 ± 0.17) 107 ± 8
Salvinorinyl-2-propionate 17.3 (1.23 ± 0.18) 102 ± 8
Salvinorin B
No activity
No activity