TABLE 2

Hemodynamic variables from protocol I (antagonist pretreatment)

Baseline
Occlusion, 30 min
Occlusion, 60 min
Reperfusion, 1 h
Reperfusion, 2 h
Reperfusion, 3 h
Vehicle
    HR (beats/min) 155 ± 3 153 ± 2 154 ± 3 154 ± 3 152 ± 2 152 ± 5
    MBP (mm Hg) 107 ± 5 105 ± 5 102 ± 5 104 ± 5 110 ± 6 109 ± 6
    LVdP/dt (mm Hg/s) 1663 ± 89 1650 ± 121 1813 ± 119 1650 ± 76 1538 ± 87 1513 ± 75
CPX
    HR 150 ± 2 153 ± 4 152 ± 4 150 ± 5 153 ± 5 151 ± 5
    MBP 90 ± 4 94 ± 7 98 ± 8 97 ± 5 102 ± 6 105 ± 6
    LVdP/dt 1650 ± 106 1481 ± 146 1631 ± 92 1506 ± 77 1538 ± 74 1538 ± 135
BG 9719
    HR 155 ± 2 161 ± 4 159 ± 4 157 ± 5 160 ± 4 161 ± 4
    MBP 104 ± 6 109 ± 5 103 ± 5 106 ± 3 114 ± 4 112 ± 5
    LVdP/dt 1838 ± 141 1931 ± 125 1819 ± 205 1706 ± 102 1781 ± 125 1725 ± 113
BG 9928
    HR 152 ± 2 150 ± 2 151 ± 4 153 ± 4 153 ± 4 154 ± 4
    MBP 87 ± 6 92 ± 5 95 ± 5 87 ± 3 97 ± 5 99 ± 4
    LVdP/dt
1518 ± 154
1631 ± 115
1650 ± 136
1463 ± 62
1463 ± 141
1463 ± 84

  • HR, heart rate; MBP, mean arterial blood pressure; LVdP/dt, maximal left ventricular dP/dt.