TABLE 1

Effect of inhibitors of ceramide synthesis upon the antiproliferative effects of CBD (25 μM) on U87 cell viability (MTT test)

U87 cells were incubated in the absence or presence of CBD and different concentrations of inhibitors. The values are expressed as mean O.D. ± S.E.M. of at least three independent experiments.

Test Compound	Control	CBD (25 μM)
l-Cycloserin (mM)
0	651±29	337±50^a
0.5	630±25	401±14^a
1	645±28	402±8.5^a
2	655±21	435±13^a
Desipramine (μM)
0	650±30	316±45^a
5	653±27	269±24^a
10	645±31	337±43^a
Fumonisin B₁ (μM)
0	570±17	320±45^a
1	585±20	300±30^a
10	568±22	340±25^a
PMA (μM)
0	590±13	293±43^a
0.05	582±16	238±22^a
0.1	588±18	245±13^a
0.2	570±25	272±10^a

↵ a p < 0.001 vs. the corresponding control values in the absence of l-cycloserine, desipramine, fumonisin B₁, and PMA.