Pathway | Inhibitor | Effect on β1-AR Agonist (Xamoterol) | Effect on β2-AR Agonist (Procaterol) | Effect on β3-AR Agonist (CL 316243) |
---|---|---|---|---|
Adenylate cyclase | ||||
G protein (Gs α) | NF 449a | NA | ↓ | ↑(?) |
AC activation | SQ 22536 | NA | ↓ | NA |
PKA activation | KT 5720 | NA | ↓ | NA |
Guanylate cyclase | ||||
G protein (Gi/o α) | NF 023 | ↓ | ↓ | ↓ |
GC activation | ODQ | ↓ | ↓ | ↓ |
PKG activation | KT 5823 | ↓ | NA(?) | ↓ |
NA, not affected; ↓, inhibition; ↑, augmentation; (?), explanations for these unanticipated observations have been given in the text
↵ a Chemical names and the respective actions of different antagonists are given in the text.