TABLE 2

Summary of effect of inhibitors of sequential events pertaining to the pathways examined, on β1-, β2-, and β3-AR activation

Pathway
Inhibitor
Effect on β1-AR Agonist (Xamoterol)
Effect on β2-AR Agonist (Procaterol)
Effect on β3-AR Agonist (CL 316243)
Adenylate cyclase
G protein (Gs α) NF 449a NA ↓ ↑(?)
AC activation SQ 22536 NA ↓ NA
PKA activation KT 5720 NA ↓ NA
Guanylate cyclase
G protein (Gi/o α) NF 023 ↓ ↓ ↓
GC activation ODQ ↓ ↓ ↓
PKG activation
KT 5823
↓
NA(?)
↓

  • NA, not affected; ↓, inhibition; ↑, augmentation; (?), explanations for these unanticipated observations have been given in the text

  • ↵ a Chemical names and the respective actions of different antagonists are given in the text.