TABLE 1

Integrated cardiovascular responses to sibutramine after pretreatment with saline, phentolamine, phentolamine plus propranolol, or propranolol

Values (mean ± S.E.M.) are areas under or over the curve (0-10 min). Superscript letters indicate significant (P < 0.05; Kruskal-Wallis test) difference from the corresponding column.

	Saline + Sibutramine	Phentolamine + Sibutramine	Phentolamine + Propranolol + Sibutramine	Propranolol + Sibutramine
	(n = 8)	(n = 9)	(n = 8)	(n = 8)
	A	B	C	D
ΔHR (beats)	+390 ± 108^BCD	+197 ± 78^AD	+104 ± 33^AD	−115 ± 52^ABC
ΔMAP (mm Hg min)	+150 ± 11^BC	−87 ± 7^AD	−115 ± 32^AD	+152 ± 28^BC
ΔCeliac Doppler shift (% min)	−142 ± 37^BC	+74 ± 40^AD	+170 ± 42^AD	−150 ± 39^BC
ΔMesenteric Doppler shift (% min)	−150 ± 24^BC	+419 ± 77^ACD	+108 ± 40^ABD	−141 ± 34^BC
ΔHindquarters Doppler shift (% min)	+446 ± 98^BCD	−162 ± 34^ACD	+66 ± 20^AB	+166 ± 47^AB
ΔCeliac vascular conductance (% min)	−231 ± 38^BC	+140 ± 40^ACD	+346 ± 50^ABD	−232 ± 37^BC
ΔMesenteric vascular conductance (% min)	−231 ± 27^BC	+525 ± 77^ACD	+284 ± 82^ABD	−213 ± 43^BC
ΔHindquarters vascular conductance(% min)	+281 ± 3^D	+148 ± 89^D	+231 ± 54^D	−92 ± 41^ABC