Population pharmacokinetic parameters and inter-individual variability of R-8-OH-DPAT, S-8-OH-DPAT, flesinoxan, buspirone, 1-PP, WAY-100,135, and WAY-100,635
The parameters CL and V denote the clearance and the volume of the central compartment, CL2 and CL3 denote the inter-compartmental clearance, whereas V2 and V3 denote the volumes of the 2nd and 3rd distribution compartments. The intra-individual variability is expressed as a coefficient of variation (CV%) between brackets.
Drug | Parameters | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CL | CL2 | CL3 | V1 | V2 | V3 | ||||||
| ml/min | ml/min | ml/min | ml | ml | ml | ||||||
| R-8-OH-DPAT | 22.8 (35) | 13.9 (96) | 69.2 (84) | 126 (38.5) | 2090 (116) | 603 (90) | |||||
| S-8-OH-DPAT | 7.86 (55) | 19.2 (41) | 76.7 (8) | 21.8 (44) | 10,000 (>1) | 692 (5) | |||||
| Flesinoxan | 2.96 (51) | 0.827 (59) | 48.1 (59) | 10.2 (70) | 226 (61) | 347 (30) | |||||
| Buspirone | 17.6 (33) | 41.7 (35) | 8.94 (96) | 626 (38) | |||||||
| 1-PP | 8.22 (31) | 123 (35) | 8.32 (131) | 924 (66) | |||||||
| WAY-100,135 | 150 (22) | 89.6 (78) | 4080 (21) | 4670 (71) | |||||||
| WAY-100,635 | 28.4 (39) | 43.8 (49) |
| 159 (>1) | 1200 (84) |
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