TABLE 1

Effects of topiramate treatment on the number of neuronal cell bodies in the hippocampus and cerebral cortex of rats subjected to lipilo-SE

Saline-Vehicle (n = 6)
Lipilo-DZP (n = 8)
Lipilo-TPM10 (n = 6)
Lipilo-TPM30 (n = 6)
Lipilo-TPM60 (n = 7)
Hippocampus
    Area CA1 66.9 ± 4.4 17.0 ± 13.1** 32.8 ± 11.7**† 33.1 ± 7.5**† 36.6 ± 18.7**†
    Area CA3a 51.1 ± 4.9 23.4 ± 7.3** 27.4 ± 7.6** 32.3 ± 13.5* 30.1 ± 14.1*
    Area CA3b 37.7 ± 2.7 26.3 ± 7.5** 31.9 ± 8.0 40.0 ± 11.6† 30.6 ± 9.2*
    Dentate gyrus hilus 67.0 ± 7.3 17.9 ± 4.6** 19.8 ± 5.5** 22.2 ± 6.8** 20.6 ± 7.3**
Cerebral cortex
    Piriform, layer II 28.0 ± 2.0 13.3 ± 8.6** 7.3 ± 7.2** 13.0 ± 11.0* 11.3 ± 9.3**
    Piriform, layer III 28.5 ± 2.4 0 ± 0** 0 ± 0** 0.7 ± 1.6** 0 ± 0**
    Dorsal entorhinal, layer II 22.2 ± 2.4 20.3 ± 8.8 15.0 ± 11.0 21 ± 10.7 19.0 ± 10.2
    Dorsal entorhinal, layers III/IV 23.0 ± 3.0 19.6 ± 11.1 15.0 ± 18.5 16.8 ± 9.7 13.7 ± 13.1
    Ventral entorhinal, layer II 22.2 ± 3.4 22.0 ± 10.8 13.2 ± 11.5 16 ± 15.1 17.0 ± 11.3
    Ventral entorhinal, layers III/IV
22.2 ± 4.9
12.4 ± 12.2
4.0 ± 6.7**
5.3 ± 9.2*
6.7 ± 10.4*

  • Values, expressed as the number of neuronal cell bodies in each area of interest, represent means ± S.D. of the number of animals written in parentheses.

  • ↵* P < 0.05, ** P < 0.01, statistically significant differences from saline-vehicle rats.

  • ↵† P < 0.05, statistically significant differences from lipilo-DZP rats.