Organ | R × 100 Valuea | % ID (mean ± S.D.) of [125I]-huC242-DM1 Conjugate in Whole Organs at Different Time Points after Intravenous Administration | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2 h | 8 h | 24 h | 48 h | 96 h | 192 h | |||||||||||||||
Blood | 8 | 50.2 | 13.0 | 35.7 | 12.2 | 24.3 | 9.4 | 26.1 | 3.6 | 21.0 | 11.1 | 11.9 | 5.1 | |||||||
Brain | 1.8 | 0.1 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.1 | 0.1 | 0.0 | 0.0 | |||||||
Thyroidb | 0.7 | 0.1 | 0.6 | 0.2 | 1.2 | 0.4 | 1.0 | 0.9 | 1.2 | 0.8 | 1.4 | 0.4 | ||||||||
Heart | 0.52 | 0.3 | 0.3 | 0.4 | 0.1 | 0.3 | 0.1 | 0.3 | 0.0 | 0.2 | 0.1 | 0.1 | 0.1 | |||||||
Lung | 0.69 | 0.7 | 0.4 | 0.7 | 0.6 | 0.4 | 0.3 | 0.3 | 0.2 | 0.3 | 0.3 | 0.2 | 0.2 | |||||||
Liver | 5.23 | 10.8 | 1.6 | 4.4 | 3.8 | 4.6 | 1.9 | 3.8 | 0.4 | 3.3 | 1.5 | 1.7 | 1.0 | |||||||
Spleen | 0.4 | 0.5 | 0.1 | 0.4 | 0.1 | 0.4 | 0.1 | 0.2 | 0.0 | 0.2 | 0.1 | 0.1 | 0.0 | |||||||
Kidney | 1.33 | 1.8 | 0.8 | 0.5 | 0.4 | 0.5 | 0.4 | 0.6 | 0.2 | 0.6 | 0.3 | 0.3 | 0.3 | |||||||
Stomach | 0.82 | 0.5 | 0.2 | 0.5 | 0.3 | 0.4 | 0.1 | 0.2 | 0.0 | 0.2 | 0.1 | 0.1 | 0.0 | |||||||
Small intestine | 2.97 | 2.1 | 0.5 | 1.6 | 0.4 | 1.6 | 0.5 | 0.9 | 0.2 | 0.8 | 0.5 | 0.4 | 0.4 | |||||||
Colon | 1.19 | 0.5 | 0.1 | 0.8 | 0.3 | 0.6 | 0.2 | 0.5 | 0.1 | 0.4 | 0.2 | 0.2 | 0.1 | |||||||
Uterus | 0.52 | 0.4 | 0.1 | 0.8 | 0.4 | 0.8 | 0.5 | 0.8 | 0.3 | 0.5 | 0.3 | 0.2 | 0.2 | |||||||
Fat | 8 | 2.0 | 0.8 | 2.0 | 0.4 | 2.2 | 0.4 | 2.1 | 1.2 | 1.7 | 0.4 | 1.1 | 0.8 | |||||||
Muscle | 40 | 9.4 | 2.6 | 9.8 | 4.6 | 10.1 | 2.6 | 9.2 | 1.7 | 6.8 | 2.9 | 3.7 | 2.2 | |||||||
Tail | 2.9 | 9.9 | 3.6 | 6.7 | 2.3 | 3.0 | 1.2 | 2.0 | 0.3 | 1.1 | 0.4 | 0.4 | 0.3 | |||||||
Total | 90.1 | 65.0 | 50.4 | 48.1 | 38.4 | 21.9 | ||||||||||||||
% Blood/total |
| 55.7 | 55.0 | 48.2 | 54.3 | 54.7 | 54.5 |
↵ a R × 102 value is the organ weight as a percentage of the total body weight (organ weight/body weight × 100) and was determined experimentally as described under Materials and Methods except for blood, muscle, and fat for which published values were used.
↵ b The whole organ was used to measure the radioactivity, and the %ID was calculated directly from the experimental value.