ED50 values with 95% C.I, of intrathecal galanin (Gal1-29), morphine (Mor), or AP-5 alone, and ED50 values of morphine/AP-5 in combination with Gal1-29 on flinching response evoked by formalin paw injection
Agents | ED50 Value (95% C.I.) | Dose Range | ||
|---|---|---|---|---|
| Phase II | Phase IIA | |||
| nmol | ||||
| Gal1-29 | 19 (8-47) | 11 (5-26) | 3-30 | |
| Mor | 4 (1-11) | 2 (1-6) | 0.3-90 | |
| Mor (+Gal1-29)a | 1 (1-2) | 1 (0.7-1.2) | 0.45-1.8 | |
| AP-5 | 60 (34-105) | 54 (37-79) | 5.6-152 | |
| AP-5 (+Gal1-29)a | 15 (10-23) | 13 (9-17) | 6.5-26 | |
↵ a The combination doses were defined by ratio of the ED50 of respective drug given alone.