TABLE 1

Effect of acute and 10-day repeated quinpirole administration on percent PPI following 73-, 76-, or 82-db prepulses

Data are expressed in terms of percent PPI ± S.E.M.

Prepulse
Quinpirole Dose (mg/kg)
0
0.05
0.1
0.3
Day 1
Day 10
Day 1
Day 10
Day 1
Day 10
Day 1
Day 10
db
73 35.8 ± 4.0 40.8 ± 5.3 20.8 ± 3.1a 31.9 ± 2.9b 17.9 ± 3.4a 20.4 ± 4a -1.0 ± 5.4c 1.0 ± 5.0a
76 52.4 ± 3.6 59.5 ± 3.1 36.9 ± 2.9a 49.5 ± 3.0b 36.0 ± 3.2a 45.4 ± 3.3a.b 10.8 ± 6.6c 17.2 ± 5.8c
82
66.9 ± 2.7
70.6 ± 3.7
46.3 ± 2.7c
63.9 ± 1.9d
46.6 ± 3.4c
60.6 ± 3.0b
34.4 ± 5.0c
41.4 ± 5.4c

  • ↵ a P ≤ 0.05 compared with same day PPI in vehicle group.

  • ↵ b P ≤ 0.05 compared with day 1 PPI within the treatment group.

  • ↵ c P ≤ 0.001 compared with same day PPI in vehicle group.

  • ↵ d P ≤ 0.001 compared with day 1 PPI within the treatment group.