TABLE 4

Noncompartmental pharmacokinetic parameters of desipramine in CYP2D6 extensive metabolizer subjects following a 50 mg oral dose in the presence and absence of atomoxetine at steady state

Parametera
Desipramine Alone (n = 21)
Desipramine + Atomoxetine (n = 21)
Cmax (ng/ml) 18.28 (45.1) 19.12 (50.2)
Tmax (h)b 6.00 (2.00-12.00) 6.00 (2.00-12.00)
AUC0-t (ng · h/ml) 639 (87.6) 699 (102.1)
AUC0-∞ (ng · h/ml) 698 (94.8) 740 (105.5)
t1/2 (h)c 23.5 (7.86-52.5) 24.5 (9.40-58.3)
CL/F (l/h/kg) 2.06 (112.2) 2.19 (145.8)
Vz/F (L/kg)
46.8 (55.1)
50.4 (80.4)

  • ↵ a Parameters are listed as arithmetic mean (CV%) unless otherwise noted.

  • ↵ b Tmax, median (range).

  • ↵ c t1/2, arithmetic mean (range).