No. | Compound | Dose | Time of Reaction on Pain Stimulus (s)a | ED50 |
---|---|---|---|---|
mg/kg | ||||
1 | Caffeine | 0.00 | 27.10 ± 1.23 | |
1.00 | 26.80 ± 2.19 | |||
3.00 | 33.00 ± 2.36 | 7.96 | ||
5.00 | 34.30 ± 1.87 | |||
10.0 | 36.90 ± 3.13* | |||
75.0 | 46.20 ± 2.74*** | |||
2 | DMPX | 0.00 | 23.60 ± 1.97 | |
10.0 | 26.10 ± 2.15 | |||
30.0 | 34.20 ± 2.72** | >50 | ||
50.0 | Lethal dose | |||
3 | Enprofylline | 0.00 | 24.60 ± 2.03 | |
10.0 | 22.30 ± 2.23 | |||
30.0 | 26.10 ± 2.38 | 56.9 | ||
50.0 | 31.30 ± 1.79 | |||
75.0 | 36.70 ± 2.55** | |||
100 | 39.50 ± 2.36*** | |||
4 | 8-SPT | 0.00 | 24.50 ± 2.14 | |
30.0 | 26.50 ± 2.32 | >100 | ||
50.0 | 23.90 ± 2.11 | |||
100 | 25.80 ± 2.28 | |||
5 | 8-SPC | 0.00 | 27.30 ± 1.92 | |
30.0 | 24.10 ± 1.80 | |||
50.0 | 25.60 ± 2.77 | >100 | ||
100 | 25.40 ± 2.21 | |||
6 | DPCPX | 0.00 | 27.10 ± 1.23 | |
10.0 | 24.10 ± 2.11 | >100 | ||
30.0 | 23.10 ± 1.93 | |||
100 | 26.10 ± 2.22 | |||
7 | PSB-36 | 0.00 | 24.40 ± 1.76 | |
30.0 | 25.10 ± 0.97 | >100 | ||
50.0 | 23.00 ± 1.96 | |||
100 | 23.40 ± 2.61 | |||
8 | MSX-3 | 0.00 | 25.90 ± 2.35 | |
30.0 | 30.20 ± 2.69 | >100 | ||
50.0 | 25.80 ± 2.39 | |||
100 | 24.40 ± 1.39 | |||
9 | PSB-10 | 0.00 | 24.70 ± 1.95 | |
30.0 | 24.20 ± 1.23 | —b | ||
50.0 | 19.80 ± 2.28 | |||
100 | 18.00 ± 1.04* | |||
10 | PSB-1115 | 0.00 | 23.50 ± 2.00 | |
6.25 | 20.90 ± 1.61 | |||
12.5 | 30.30 ± 1.92 | 27.74 | ||
25.0 | 30.40 ± 2.60 | |||
50.0 | 33.30 ± 1.63** | |||
100 | 37.10 ± 2.34*** | |||
11 | PSB-53 | 0.00 | 27.20 ± 2.11 | |
12.5 | 25.90 ± 2.29 | |||
25.0 | 31.00 ± 3.08 | 50 | ||
50.0 | 34.80 ± 1.24 | |||
75.0 | 38.90 ± 2.19** | |||
100 | 43.00 ± 1.86*** | |||
12 | PSB-50 | 0.00 | 27.20 ± 2.11 | |
12.5 | 25.30 ± 1.78 | |||
25.0 | 25.60 ± 2.74 | >100 | ||
50.0 | 33.80 ± 1.50* | |||
75.0 | 36.50 ± 2.05 | |||
100 | 26.20 ± 2.34 | |||
13 | PSB-55 | 0.00 | 27.90 ± 1.75 | |
30.0 | 27.50 ± 2.28 | >100 | ||
50.0 | 28.40 ± 2.07 | |||
100 | 36.80 ± 3.01* | |||
14 | Codeine sulfate | 0.00 | 26.20 ± 1.99 | |
5.00 | 23.88 ± 1.27 | >50 | ||
20.0 | 25.98 ± 2.24 | |||
50.0 | 36.25 ± 3.90* | |||
15 | Morphine-HCl | 0.00 | 26.20 ± 1.99 | |
3.00 | 29.30 ± 2.16 | |||
5.00 | 25.20 ± 2.56 | |||
10.0 | 31.50 ± 2.05 | 18.1 | ||
15.0 | 33.60 ± 4.76 | |||
30.0 | 54.50 ± 2.82*** | |||
50.0 | 55.30 ± 3.18*** | |||
16 | Acetylsalicylic acid | 0.00 | 27.10 ± 1.23 | |
250 | 27.20 ± 1.10 | >1000 | ||
500 | 30.40 ± 1.28 | |||
|
| 1000 | 33.10 ± 2.44* |
|