Treatment (n) | EC50 (mosM)c (95% CI) | Maximum Response | ||||
---|---|---|---|---|---|---|
Relaxation (Percentage of MCh)a | Depolarization ΔVt (mV)b | Relaxation (Percentage of MCh) | Depolarization ΔVt (mV) | |||
Saline (7) | 11.4 (8.2-15.8) | 121.6 (75.0-197.2)d | 78.2 ± 6.2 | 15.3 ± 0.5 | ||
LPS (6) | 10.4 (8.4-12.8) | 183.6 (120.2-280.4)e | 113.3 ± 9.5f | 38.0 ± 4.1f |
↵ a Relaxation responses (centimeters of H2O) were normalized as a percentage of the extraluminal MCh-induced contraction; saline- and LPS-treated, n = 8
↵ b Values refer to the change of Vt after the administration of extraluminal MCh; saline- and LPS-treated, n = 4
↵ c Values refer to milliosmoles of NaCl added to the intraluminal MKHS
↵ d Significantly greater than saline (relaxation)
↵ e Significantly greater than LPS (relaxation)
↵ f Significantly greater than saline-treated controls