Effect of LPS treatment on in vitro reactivity to MCh in epithelium-denuded perfused trachea The tracheas were removed from the animals 18 h post-treatment.
Treatment (n) | EC50 (M) (95% CI) | Maximum Response ΔP (cm H2O) | IL/EL Maximum Response Ratioa | ||||
|---|---|---|---|---|---|---|---|
| EL | IL | EL | IL | ||||
| Saline (4) | 2.1×10-6 (0.8-5.2) | 7.7×10-6 (2.0-30.0) | 3.8 ± 0.7 | 3.5 ± 0.6 | 0.97 ± 0.12 | ||
| LPS (4) | 1.1×10-6 (0.5-2.2) | 1.5×10-6 (0.8-2.8) | 3.9 ± 0.4 | 3.5 ± 0.3 | 1.00 ± 0.06 | ||