TABLE 1

Response of mesenteric arteries and veins from sham control and DOCA-salt mice to the adrenergic agonists PE and NE. Data are expressed as mean ± S.E.M. Numbers in parentheses refer to the number of animals from which the data were obtained. Emax is the maximum constriction based on data fitted to a logistic equation. EC50 is the negative logarithm of the molar concentration of agonist producing half-maximal constriction.



Emax

EC50

Vein
Artery
Vein
Artery
% -log M
NE
   SHAM 40.6 ± 7.5 (4) 39.3 ± 11.7 (5) 7.2 ± 0.2a(4) 5.7 ± 0.1 (5)
   DOCA-salt 48.8 ± 6.0 (5) 31.9 ± 3.7 (4) 6.8 ± 0.2a(5) 5.5 ± 0.01 (4)
PE
   SHAM 30.5 ± 2.8 (4) 32.9 ± 5.0 (5) 7.1 ± 0.2a(4) 5.3 ± 0.1 (5)
   DOCA-salt
31.0 ± 3.7 (4)
34.2 ± 3.7 (5)
6.8 ± 0.3a(4)
5.2 ± 0.05 (5)
  • a Significantly different compared with respective artery EC50