Radioligand binding affinity (Ki, nM) for PD168077, CP226269, and apomorphine on recombinant human D4 variants hD4.2, hD4.4, and hD4.7 Competition binding with [3H]spiperone for dopaminergic receptor agonists. Data are presented as mean ± S.E.M. (n = 4).
Compound | hD4.2 | hD4.4 | hD4.7 |
|---|---|---|---|
| Apomorphine | 8.1 ± 0.4 | 9.6 ± 0.6 | 9.3 ± 0.7 |
| PD168077 | 6.0 ± 2.8 | 22.3 ± 0.1 | 29.0 ± 1.3 |
| CP226269 | 2.4 ± 0.7 | 3.6 ± 0.1 | 5.6 ± 0.9 |