TABLE 3

Inhibitory effects of i.c.v microinjection of haloperidol or clozapine on penile erection facilitated by apomorphine (0.1 μmol/kg s.c.) in conscious Wistar rats Penile erection was assessed during a 60-min post-dosing period. Data are expressed as erection incidence (%) ± S.E. (n = 8).


Treatmenta

Dose

Incidence (%)
μmol / kg i.c.v.
Apomorphine
+ haloperidol 0.001 100 ± 0
+ haloperidol 0.003 71 ± 17
+ haloperidol 0.01 43 ± 19**
+ haloperidol 0.03 29 ± 17**
+ haloperidol 0.1 14 ± 13***
Apomorphine 75 ± 15
+ clozapine 0.01 57 ± 19
+ clozapine 0.03 57 ± 19
+ clozapine
0.1
14 ± 13**
  • a Dopaminergic antagonists were administered i.p. 15 min before s.c. apomorphine injection (0.1 μmol/kg)

  • * p < 0.05

  • ** p < 0.01

  • *** p < 0.001, compared with apomorphine control