TABLE 1

Sequence comparison of GAS element in the promoter of CYP2E1 and other IFN-γ-inducible genes

GAS Sequence
Gene
Regulator
GGTTTCCGGGAAAGCa Human ICAM (intercellular adhesion molecule) IFN-γ
TGTTTCTGAGAATCTa Human IFP53 (tryptophanyl tRNA synthetase) IFN-γ
TCCTTCTCAGAACACa,b Human CYP2E1 ?
TCCTTCTCAaGGATAC Rat CYP2E1 ?
TCCTTCTCAtGAACAC
Mouse CYP2E1
?

  • ↵ a The consensus sequences for GAS elements are shown in bold type

  • ↵ b The —71G in the human CYP2E1 gene is underlined. Rat CYP2E1 sequence (Umeno, 1988), lowercase nucleotides indicate insertions found in the mouse and rat genes in comparison to the human gene