Colonic mucosal sheets isolated from F344 and HLA-B27 rats receiving oral treatment with placebo or rhIL-11 administered a dose of 500 μg/kg every other day during 2 weeks Paracellular resistance (R) was calculated for the ascending and descending phase of the response to SP (1 μM) as described under Materials and Methods. Data are mean ± SEM from n = 6 rats for each group and the 95% CI are given in parentheses. There was no significant difference between the paracellular resistance estimated from the upward and downward phase of the response to SP for each group. One-way ANOVA of the data for each phase showed that the variation among group means is significant (P < 0.0001).
Group | Treatment | Paracellular R (Ω/cm2) | ||
|---|---|---|---|---|
| Ascending Phase | Descending Phase | |||
| HLA-B27 (n = 6) | Placebo | 17 ± 2b,c,d (12-22) | 16 ± 2b,c,d (11-20) | |
| HLA-B27 (n = 6) | rhIL-11 | 30 ± 2a,d (24-36) | 31 ± 2a (27-35) | |
| F344 (n = 6) | Placebo | 40 ± 2a (34-45) | 40 ± 3a (33-47) | |
| F344 (n = 6) | rhIL-11 | 45 ± 2a,c (39-50) | 39 ± 2a (34-45) | |
Differences between groups are indicated as follows: a significantly different from placebo-treated HLA-B27 rats; b significantly different from placebo-treated F344 rats; c significantly different from rhIL-11 treated HLA-B27 rats; d significantly different from rhIL-11 treated F344 rats.