Summary of anticonvulsant effects in rats ED50 values were calculated by the probit method (95% confidence limits are shown in parentheses).
ED50 (mg/kg) | |||
|---|---|---|---|
| MES | PTZ | ||
| YM928 | 4.0 | 6.2 | |
| (3.1-5.0) | (4.4-8.5) | ||
| Carbamazepine | 8.1 | >400 | |
| (5.2-12.0) | (-) | ||
| Phenytoin | 9.1 | >600 | |
| (6.3-13.6) | (-) | ||
| Lamotrigine | 5.2 | >200 | |
| (4.1-6.7) | (-) | ||
| Valproate | 212 | 255 | |
| (164-257) | (215-304) | ||
| Phenobarbital | 8.8 | 13.7 | |
| (7.0-10.8) | (10.0-19.1) | ||
| Diazepam | 4.7 | 0.83 | |
| (2.3-7.0) | (0.53-1.3) | ||
| Ethosuximide | >1000 | 267 | |
|
| (-) | (194-350) | |
MES, maximal electroshock seizure test; PTZ, pentylenetetrazol-induced seizure test.