Effects of delayed chronic oral SB-239063AN treatment on vasoactivity in SHR-SPs
Group | Norepinephrine | Carbachol | Sodium nitroprusside | ||||||
|---|---|---|---|---|---|---|---|---|---|
| EC50 (nM) | Rmax (% response to 60 mM KCl) | EC50 (nM) | Rmax (% reversal of NE-induced tone) | EC50 (nM) | Rmax (% reversal of NE-induced tone) | ||||
| Normal diet, control (n = 8) | 11.1 ± 1.1 | 108.0 ± 2.7 | 352 ± 57## | 85.1 ± 2.8## | 4.2 ± 1.0### | 100 | |||
| Salt/fat diet, control (n = 10) | 9.2 ± 1.3 | 101.2 ± 3.1 | 819 ± 112†† | 67.5 ± 3.1†† | 11.8 ± 1.3††† | 100 | |||
| SB-239063AN (1500 ppm; n = 7) | 12.5 ± 0.7 | 93.2 ± 2.1†† | 318 ± 60## | 85.1 ± 3.9## | 8.5 ± 0.3† | 100 | |||
All values are expressed as mean ± S.E.M. and n represents the number of animals studied. Statistical comparisons were performed using one-way analysis of variance with a Tukey-Kramer multiple comparisons post test.
↵† P < 0.05, ††P < 0.01, and †††P < 0.001 vs. normal diet control and #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. salt/fat diet control.