TABLE 1

Effects of α 1-adrenoceptor antagonists on the isoferulic acid-induced changes of BER and glucose concentrations in plasma of STZ-diabetic rats

The antagonists were given by i.v. injection 30 min before the injection of isoferulic acid. Vehicle (0.9% NaCl in distilled water) was given at the same volume. Values (mean ± S.E.M.) were obtained from each group of eight animals. Basal level shows the value from fasted animals treated with vehicle.

Plasma Glucose
Plasma BER
mM pg/ml
Basal 27.8 ± 2.5 47.3 ± 4.2
Isoferulic acid (5.0 mg/kg i.v.)
    + vehicle 17.9 ± 3.1** 111.3 ± 3.9**
    + tamsulosin (mg/kg, i.v.)
        0.25 22.4 ± 2.3* 96.2 ± 5.3**
        0.5 26.4 ± 1.9 74.5 ± 6.1*
        1.0 28.0 ± 2.6 49.0 ± 5.9
    + WB 4101 (mg/kg i.v.)
        0.1 21.3 ± 2.2* 99.3 ± 4.8**
        0.5 25.7 ± 2.8 80.2 ± 4.6*
        1.0 27.2 ± 3.4 50.3 ± 5.2
Tamsulosin (1.0 mg/kg i.v.) 28.9 ± 4.2 46.2 ± 5.1
WB 4101 (1.0 mg/kg i.v.)
28.0 ± 3.9
47.0 ± 4.9

  • ↵* p < 0.05 and **p < 0.01 versus basal value, respectively.