AUCblood and CLtotal of PL and butyryl-PL after intravenous administration in rats and dogs
Dosing Compound | Rata | Dog |
|---|---|---|
| PL | ||
| AUCblood,pl (ng · h/ml) | 649 | 1052 ± 219 |
| CLtotal,pl (l/h/kg) | 3.85 | 1.90 ± 0.61 |
| Butyryl-PL | ||
| AUCblood,Bu (ng · h/ml) | 433 | 30.5 ± 8.60 |
| AUCblood,Bu→pl (ng · h/ml) | 289 | 1103 ± 310 |
| CLtotal,Bu (l/h/kg) | 5.77 | 65.6 ± 18.6 |
| Blood flow (l/h/kg) | ||
| Liver | 3.6 | 1.9 |
| Cardiac output | 17.8 | 7.2 |
↵ a Parameters were calculated from mean blood concentration after intravenous administration of PL and butyryl-PL in rats (2.5 mg/kg for rats, equivalent to PL). AUC of drugs after administration in rats was calculated from mean plasma concentrations from time zero to infinity. AUCblood = AUCplasma × Rb. AUCblood,pl means the AUCblood of PL after administration of PL. AUCblood, Bu and AUCblood, Bu→pl mean the AUCblood of butyryl-PL and PL after administration of butyryl-PL, respectively. CLtotal,pl and CLtotal,Bu mean the total clearance of PL and butyryl-PL after administration of PL and butyryl-PL, respectively.