Effects of opioid μ -receptor antagonists on the isoferulic acid-induced lowering of plasma glucose in STZ-diabetic rats
The antagonists were given by i.v. injection 30 min before the injection of isoferulic acid. Vehicle (0.9% NaCl in distilled water) was given at the same volume. Values (mean ± S.E.M.) were obtained from each group of seven animals. Basal level shows the value from fasted animals treated with vehicle.
Plasma Glucose (mM) | |
|---|---|
| Basal | 28.2 ± 4.1 |
| Isoferulic acid (5.0 mg/kg i.v.) | |
| + vehicle | 17.5 ± 2.7** |
| + naloxone (mg/kg i.v.) | |
| 1.0 | 20.1 ± 3.1* |
| 5.0 | 25.8 ± 2.8 |
| 10.0 | 28.4 ± 3.7 |
| + Naloxonazine (mg/kg i.v.) | |
| 1.0 | 22.3 ± 2.2* |
| 5.0 | 26.6 ± 3.0 |
| 10.0 | 29.0 ± 4.5 |
| Naloxone (10.0 mg/kg i.v.) | 28.5 ± 3.6 |
| Naloxonazine (10.0 mg/kg i.v.) | 28.7 ± 4.3 |
↵* p < 0.05 and **p < 0.01 versus basal value, respectively.