Effect of chronic nicotine on α3β4-like binding
Region | Saline-Treated | Nicotine-Treated | Percentage of Control | |
|---|---|---|---|---|
| fmol/mg ± S.E.M. | ||||
| Visual cortex, layer 6 | 0.49 ± 0.074 | 0.37 ± 0.16 | 77 | |
| Medial habenula | 85 ± 6.7 | 94 ± 4.2 | 112 | |
| Fasciculus retroflexus | 32 ± 3.5 | 31 ± 1.2 | 97 | |
| Interpeduncular nucleus | 81 ± 9.5 | 67 ± 5.9 | 83 | |
| Retrosplenial cortex, layer 1 | 0.54 ± 0.13 | 0.25 ± 0.23 | 46 | |
| Subiculum | 2.0 ± 0.16 | 0.96 ± 0.12 | 48*** | |
| Substantia nigra, pars compacta | 0.82 ± 0.18 | 0.59 ± 0.41 | 72 | |
| Ventral tegmental area | 2.4 ± 0.16 | 1.9 ± 0.24 | 78 | |
| Optic tract | 2.0 ± 0.22 | 2.5 ± 0.27 | 126 | |
| Cerebellum, granular layer | 1.3 ± 0.028 | 1.17 ± 0.025 | 91* | |
| Nucleus of the solitary tract, medial | 4.0 ± 0.55 | 3.2 ± 0.87 | 81 | |
| Dorsal motor nucleus of the vagus | 3.8 ± 0.30 | 5.2 ± 0.36 | 136* | |
| Spinal trigeminal nucleus | 2.0 ± 0.14 | 2.4 ± 0.29 | 121 | |
| Area postrema | 7.8 ± 0.45 | 7.3 ± 0.44 | 93 | |
| Pineal gland | 16 ± 3.8 | 17 ± 1.6 | 107 | |
↵* p < 0.05; *** p < 0.001, compared to saline controls.