Effects of morphine and SB-235863 on gastrointestinal motility
Compound | Peroral Dose | Percentage of Gastrointestinal Transit |
|---|---|---|
| mg/kg | ||
| Vehicle | N/A | 32.8 ± 1.7 |
| Morphine | 3.9 | 16.5 ± 1.5* |
| SB-235863 | 70 | 36.8 ± 3.0 |
N/A, not applicable.
↵* P < 0.05 compared with rats injected with vehicle (Dunnett's test). The test procedures used and methods for analysis and expression of data are described under Materials and Methods. Data are the mean ± S.E.M. of results from six animals.