TABLE 2

Log P values and permeability data for d4T and the probes mannitol and propranolol in Caco-2 cell monolayers obtained in 120-min transport experiments

	Log P	Permeability^a
		cm/s × 10^-6
d4T	0.5^b	4.5 ± 0.5
Mannitol	-2.0^b	1.2 ± 0.1
Propranolol	1.5^c	19.2 ± 0.4

↵ a Values represent the mean ± S.D. of n = 6.
↵ b Value calculated using CS ChemDraw Ultra 7.0 (CambridgeSoft, Cambridge, MA).
↵ c Measured octanol/buffer partition coefficient at pH 7.4.