Predicted additive ED5°C values (Zadd) and experimentally determined ED5°C values (Zmix) of mixtures of SNC80 administered in combination with the μ agonists methadone, fentanyl, morphine, and nalbuphine or the κ agonists U69,593 and bremazocine in an assay of thermal nociception
Zadd and Zmix values show the total dose of SNC80 + agonist in the mixture in milligrams per kilogram (95% confidence limits). The proportion of SNC80 is shown for each mixture.
Mixture | Zadd (95% CL) | Zmix (95% CL) |
|---|---|---|
| SNC80 + methadone | ||
| 0.10:1 SNC80/methadone | 1.8 (1.4-2.2) | 0.93 (0.48-1.8) |
| 0.30:1 SNC80/methadone | 2.1 (1.7-2.7) | 0.60 (0.38-0.92)** |
| 0.90:1 SNC80/methadone | 3.1 (2.5-3.9) | 0.60 (0.43-0.83)** |
| SNC80 + fentanyl | ||
| 10:1 SNC80/fentanyl | 0.16 (0.13-0.20) | 0.10 (0.059-0.18) |
| 31:1 SNC80/fentanyl | 0.46 (0.37-0.57) | 0.20 (0.13-0.31)* |
| 93:1 SNC80/fentanyl | 1.3 (1.1-1.7) | 0.41 (0.28-0.60)* |
| SNC80 + morphine | ||
| 0.032:1 SNC80/morphine | 3.6 (3.0-4.4) | 3.1 (2.3-4.1) |
| 0.096:1 SNC80/morphine | 3.9 (3.2-4.6) | 2.8 (2.5-3.3) |
| 0.29:1 SNC80/morphine | 4.6 (3.8-5.4) | 1.7 (1.1-2.5)* |
| SNC80 + nalbuphine | ||
| 0.40:1 SNC80/nalbuphine | 2.1 (0.88-4.9) | 1.6 (1.2-2.3) |
| 1.2:1 SNC80/nalbuphine | 3.2 (1.4-7.6) | 0.81 (0.48-1.4)* |
| 3.6:1 SNC80 nalbuphine | 6.7 (2.8-15.7) | 0.83 (0.55-1.3)** |
| SNC80 + U69,593 | ||
| 9.3:1 SNC80/U69,593 | 0.18 (0.11-0.30) | 0.28 (0.12-0.70) |
| 28:1 SNC80/U69,593 | 0.51 (0.31-0.84) | 0.62 (0.26-1.5) |
| 84:1 SNC80/U69,593 | 1.5 (0.90-2.5) | 1.5 (0.90-2.6) |
| SNC80 + bremazocine | ||
| 130:1 SNC80/bremazocine | 0.33 (0.16-0.68) | 0.28 (0.25-0.33) |
| 390:1 SNC80/bremazocine | 1.0 (0.49-2.0) | 0.41 (0.21-0.80)* |
| 1200:1 SNC80/bremazocine | 3.0 (1.5-6.0) | 1.3 (0.43-4.0)* |