Effect of hemin on NOS-2 activity
Data are the mean ± S.E.M. of six animals. NOS-2 activity was determined in cytosolic fractions from leukocytes present in pouch exudates.
NOS-2 Activity | |||
|---|---|---|---|
| 24 h | 48 h | ||
| pmol l-citrulline / mg protein / 60 min | |||
| Saline | 56.0 ± 6.0 | 49.0 ± 4.0 | |
| Hemin | 108.5 ± 28.0 | 72.5 ± 13.2 | |
| Zymosan | 435.5 ± 63.0 | 330.5 ± 36.0 | |
| Zymosan + hemin | 295.5 ± 40.5* | 0.0 ± 0.0** | |
↵* p < 0.05, ** p < 0.01 compared with the zymosan group.