TABLE 2

Effect of chronic ethanol on lateral/basolateral amygdala NMDA receptor subunit expression

Expression levels are relative to total forebrain RNA and are normalized GAPDH expression in the same samples.

Gene
Treatment
Control
Chronic Ethanol
NR1a 22.0 ± 1.4 28.0 ± 1.5*
NR2A 19.1 ± 1.9 16.4 ± 1.5
NR2B 20.9 ± 2.5 19.6 ± 2.4
NR2C 48.5 ± 3.0 48.6 ± 2.9
NR2D 8.1 ± 0.6 8.8 ± 1.0
NR3A 44.8 ± 3.1 46.5 ± 2.1
NR3B
10.0 ± 0.5
10.9 ± 0.7

  • ↵* P < 0.05, two-tailed t test.

  • ↵ a For NR1, NR3A, and NR3B, n = 6 control and 8 chronic ethanol animals. For the other subunits, n = 8 control and 9 chronic ethanol animals.