Population parameter estimates (Θ ± S.E.) for the drift in time of the parameters KPD, ePD and A and the corresponding MVOF for the concentration-effect data upon administration of alphaxalone alone
Intraindividual residual variation was 11%.
Parameter | Change in Time | Estimate ± S.E. min−1 | MVOF |
|---|---|---|---|
| None | 5854 | ||
| K PD | D 1 | 1.5 · 10−3 ± 3.2 · 10−4 | 5322a |
| e PD | D 2 | 7.1 · 10−4 ± 2.9 · 10−6 | 5353a |
|
A
|
D
3
| 1.6 · 10−3 ± 0.3 · 10−4 | 5419a |
↵ a Significantly lower compared with no change in time of a parameter, p < 0.05.