TABLE 2

LD50 values for amiodarone and desethylamiodarone in different cell lines after 48 h of incubation


Cell Lines

Amiodarone

Desethylamiodarone
μM ± S.E.M. μM ± S.E.M.
H9C2 49.1 ± 5.8 17.2 ± 3.9a
BRL-3A 13.3 ± 4.2 4.2 ± 1.1a
WRL-68 2.4 ± 0.4 2.5 ± 0.3
PANC-1
41.4 ± 3.7
23.5 ± 1.4a
  • a Significant differences between the LD50 of amiodarone and desethylamiodarone (p < 0.01, paired t test, n = 8).